Petco carries two brands that eliminate fleas in dogs: Nexgard and Bravecto. Nexgard is a beef-flavored soft chew safe for use on dogs and puppies 8 weeks or older, weighing 4 or more pounds. This prescription is administered orally once a month and can be given with or without food. The active ingredient afoxolaner kills fleas and ticks in dogs by over-stimulating their nervous system. Afoxolaner is not safe for use on cats.
Bravecto chewable tablets or topical solutions are safe for use on dogs and puppies 6 months or older, weighing 4.4 or more pounds. It is also approved for use in breeding, pregnant, and lactating dogs. Only the topical is safe for use on cats and kittens 6 months or older, weighing 2.6 or more pounds. While this is true, you should never use dog products on cats and vice versa.
Bravecto chewable tablets are administered once every 12 weeks, a major difference from OTC treatments. Unlike with Nexgard, a single dose of Bravecto Chew must be given orally with food. To apply topical solutions, part your dog's hair and apply the product to the skin between the shoulder blades. The active ingredient fluralaner works by preventing the flea and tick nervous systems from fully functioning.